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. 2021 Apr 19;12:581799. doi: 10.3389/fimmu.2021.581799

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Copyright © 2021 Hartwig, Loebel, Steiner, Bauer, Karadeniz, Roeger, Skurk, Scheibenbogen and Sotzny

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metformin reduces ROS/RNS level in human immune cells in a dose-dependent manner. (A–D) ROS/RNS level was measured in blood immune cells, cultured with metformin for 3 h (n=6; met alone n=2). Cells were either unstimulated or stimulated with PMA [100 ng/ml] for 10 min and ROS/RNS generation was measured by FC in (A) T cells, (B) B cells, (C) monocytes and (D) NK cells using DCFH-DA. Median with interquartile range is depicted and Wilcoxon test is used for statistical analysis. *P ≤ 0.05.