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. 2021 Apr 19;12:581799. doi: 10.3389/fimmu.2021.581799

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Copyright © 2021 Hartwig, Loebel, Steiner, Bauer, Karadeniz, Roeger, Skurk, Scheibenbogen and Sotzny

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FOXO3 gain-of-function SNPs have no influence on ROS/RNS level. ROS/RNS level in CD14⁺ monocytes were investigated following stimulation with PMA [100 ng/ml] for 10 min by DCFH-DA staining using FC. (A) rs12212067 SNP carrier minor/heterozygous n=12 and major n=30. Minor allele carrier is depicted with an open circle (○). (B) rs2802292 SNP carrier minor n=10, heterozygous n=21 and major n=11 and (C) rs12206094 SNP carrier: minor n=4, heterozygous n=21 and major n=17. Median with interquartile range is depicted and Mann-Whitney test is used for statistical analysis between independent cohorts.