Table 2.
Univariable and multivariable Cox analysis for predicting overall survival in T1–2 breast cancer with 1–3 positive lymph nodes in the control cohort.
| Characteristic | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|
| HR(95%CI) | P | HR(95%CI) | P | |
| Marital Status | <0.001 | <0.001 | ||
| USDW | ||||
| Married | 0.618(0.561–0.681) | 0.687(0.622–0.759) | ||
| Age | <0.001 | <0.001 | ||
| 20–39 | ||||
| 40–49 | 0.740(0.612–0.895) | 0.002 | 0.805(0.666–0.974) | 0.026 |
| 50–59 | 0.984(0.821–1.178) | 0.858 | 0.993(0.828–1.190) | 0.973 |
| 60–69 | 1.603(1.346–1.909) | <0.001 | 1.633(1.368–1.949) | <0.001 |
| Race | <0.001 | <0.001 | ||
| White | ||||
| Black | 1.456(1.270–1.670) | <0.001 | 1.163(1.011–1.338) | 0.035 |
| Other | 0.702(0.582–0.847) | <0.001 | 0.706(0.585–0.852) | <0.001 |
| Histology | 0.001 | 0.132 | ||
| Infiltrating duct cancer | ||||
| Infiltrating Lobular carcinoma | 0.728(0.599–0.884) | 0.856(0.0.700–1.048) | ||
| Grade | <0.001 | <0.001 | ||
| 1 | ||||
| 2 | 1.379(1.141–1.666) | 0.001 | 1.280(1.058–1.550) | 0.011 |
| 3 | 2.268(1.890–2.722) | <0.001 | 1.632(1.342–1.985) | <0.001 |
| Laterality | 0.461 | |||
| Left | ||||
| Right | 1.037(0.941–1.143) | |||
| T stage | <0.001 | <0.001 | ||
| T1 | ||||
| T2 | 1.882(1.696–2.088) | 1.703(1.532–1.893) | ||
| Chemotherapy | <0.001 | <0.001 | ||
| No | ||||
| Yes | 0.742(0.669–0.824) | 0.718(0.646–0.799) | ||
| ALND | <0.001 | 0.180 | ||
| Yes | ||||
| No | 1.218(1.096-1.355) | 1.077(0.966-1.200) | ||
| Examined lymph nodes | 0.001 | <0.001 | ||
| 4–12 | ||||
| >12 | 0.817(0.741–0.901) | 0.758(0.687–0.837) | ||
| Positive lymph nodes | <0.001 | <0.001 | ||
| 1 | ||||
| 2 | 1.181(1.056–1.320) | 0.258 | 1.192(1.065–1.334) | 0.002 |
| 3 | 1.723(1.517–1.957) | <0.001 | 1.706(1.499–1.941) | <0.001 |
| ER | <0.001 | <0.001 | ||
| Negative | ||||
| Positive | 0.492(0.444–0.546) | 0.698(0.600–0.812) | ||
| PR | <0.001 | <0.001 | ||
| Negative | ||||
| Positive | 0.510(0.462–0.562) | 0.740(0.643–0.851) | ||
USDW, unmarried/separated/divorced/widowed; Other, American Indian/AK Native, Asian/Pacific Islander; grade 1, well differentiated; grade 2, moderately differentiated; grade 3, poorly differentiated/undifferentiated; ALND, axillary lymph node dissection; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2.