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. 2021 Mar 31:1–10. doi: 10.1159/000515132

Table 3.

Overview of previous studies [9, 13–16, 35]

Study Method of chemosensory assessment Population, n (mean age, years) Follow-up time, mean (days) Olfactory function at follow-up Gustatory function at follow-up
Chiesa-Estomba et al. [35] Prospective, survey-based, telemedicine 751 (41) 47.7 Full recovery: 49%;
improvement: 14%;
no improvement: 37%

Vaira et al. [9] Connecticut Chemosensory Clinical Research Center orthonasal olfaction test (hospitalized patients) or self-administered olfactory and gustatory psychophysical test (home-quarantined patients) 138 (51.2) 60 5.8% with severe dysfunction 4.3% with severe dysfunction

Amer et al. [13] Prospective, questionnaire-based 96 (34.3) 30 Full recovery: 33.3%;
improvement: 41.7%;
no improvement: 25%

Brandão Neto et al. [14] Prospective, interview-based 655 (37.7) 76 Full recovery: 53.8%;
partial improvement: 44.7%;
no improvement: 1.4%
Full recovery: 68.3%;
partial improvement: 27.6%; no
improvement: 4.1%

Otte et al. [16] Olfaction was tested using Sniffin' Sticks (Burghart Messtechnik GmbH, Wedel, Germany), and gustation was tested using taste sprays 91 (43.01) 57.9 Hyposmia: 45.1%;
normal range: 53.8%

Iannuzzi et al. [15] Sniffin' Sticks (Burghart Messtechnik GmbH, Wedel, Germany) 30 (47.5) ˜55 27% remained hyposmic; no patients remained anosmic

Only studies that have looked into improvement and recovery from COVID-19-related chemosensory dysfunction with follow-up times of more than 1 month were included.