Table 3.
Study | Method of chemosensory assessment | Population, n (mean age, years) | Follow-up time, mean (days) | Olfactory function at follow-up | Gustatory function at follow-up |
---|---|---|---|---|---|
Chiesa-Estomba et al. [35] | Prospective, survey-based, telemedicine | 751 (41) | 47.7 | Full recovery: 49%; improvement: 14%; no improvement: 37% |
|
Vaira et al. [9] | Connecticut Chemosensory Clinical Research Center orthonasal olfaction test (hospitalized patients) or self-administered olfactory and gustatory psychophysical test (home-quarantined patients) | 138 (51.2) | 60 | 5.8% with severe dysfunction | 4.3% with severe dysfunction |
Amer et al. [13] | Prospective, questionnaire-based | 96 (34.3) | 30 | Full recovery: 33.3%; improvement: 41.7%; no improvement: 25% |
|
Brandão Neto et al. [14] | Prospective, interview-based | 655 (37.7) | 76 | Full recovery: 53.8%; partial improvement: 44.7%; no improvement: 1.4% |
Full recovery: 68.3%; partial improvement: 27.6%; no improvement: 4.1% |
Otte et al. [16] | Olfaction was tested using Sniffin' Sticks (Burghart Messtechnik GmbH, Wedel, Germany), and gustation was tested using taste sprays | 91 (43.01) | 57.9 | Hyposmia: 45.1%; normal range: 53.8% |
|
Iannuzzi et al. [15] | Sniffin' Sticks (Burghart Messtechnik GmbH, Wedel, Germany) | 30 (47.5) | ˜55 | 27% remained hyposmic; no patients remained anosmic |
Only studies that have looked into improvement and recovery from COVID-19-related chemosensory dysfunction with follow-up times of more than 1 month were included.