Table 1.
Baseline Characteristics of Patients Categorized by CT Findings (n=466)
| Variable | Total (n=466) | Unilateral lesion (n=372) | Bilateral normal (n=55) | Bilateral lesion (n=39) | P value |
|---|---|---|---|---|---|
| Age, yr | 51.0 (43.0–59.0) | 51.0 (43.5–59.0) | 47.0 (36.0–60.5) | 58.0 (51.0–64.0)b,c | 0.003 |
| Female sex | 231 (49.6) | 189 (50.8) | 28 (50.9) | 14 (35.9) | 0.204 |
| Height, cm | 163.7 (157.6–170.0) | 163.3 (157.4–169.8) | 163.3 (156.2–170.9) | 167.6 (160.2–172.4) | 0.145 |
| Weight, kg | 67.4 (57.9–76.5) | 67.1 (57.3–76.1) | 66.0 (57.2–75.8) | 71.5 (64.5–80.1) | 0.077 |
| BMI, kg/m2 | 25.2 (22.7–27.3) | 25.2 (22.6–27.2) | 24.6 (22.3–26.7) | 25.9 (24.1–28.0) | 0.122 |
| Systolic BP, mm Hg | 142.0 (131.0–156.0) | 142.0 (132.0–155.0) | 150.0 (131.5–160.0) | 135.0 (125.5–153.5) | 0.082 |
| Diastolic BP, mm Hg | 90.0 (81.0–98.0) | 90.0 (81.0–97.0) | 91.0 (81.0–100.0) | 87.0 (77.5–97.0) | 0.262 |
| Antihypertensive drug, DDD | 2.0 (1.0–3.4) | 2.0 (1.0–3.5) | 1.0 (0.0–2.7)a | 2.0 (1.0–3.5) | 0.039 |
| eGFR, mL/min/1.73 m2 | 88.3 (75.2–104.5) | 88.0 (75.8–103.5) | 90.1 (74.8–107.3) | 84.7 (73.5–110.2) | 0.838 |
| Serum potassium, mEq/L | 3.4 (3.0–4.0) | 3.3 (2.9–3.9) | 3.9 (3.5–4.2)a | 3.6 (3.0; 4.2) | <0.001 |
| Hypokalemia | 228 (51.1) | 207 (55.6) | 12 (21.8)a | 19 (48.7)c | <0.001 |
| PAC, ng/dL | 30.5 (23.4–45.2) | 31.3 (24.1–47.2) | 26.3 (19.7–34.0)a | 28.9 (21.9;41.9) | 0.001 |
| PRA, ng/mL/hr | 0.2 (0.1–0.4) | 0.2 (0.1–0.4) | 0.2 (0.1–0.5) | 0.2 (0.2–0.3) | 0.321 |
| ARR, ng/dL per ng/mL/hr | 146.5 (75.3–300.0) | 163.0 (76.2–320.5) | 96.0 (57.9–192.6)a | 130.0 (91.0–239.2) | 0.012 |
| Nodule size on CT, cm | 1.5 (1.1–1.8) | 1.5 (1.1–1.8) | NA | 1.5 (1.1–1.8) | 0.182 |
Values are expressed as median (interquartile range) or number (%). α<0.017 was considered to be statistically significant after post hoc Bonferroni correction for multiple testing (α=0.05/3=0.0167).
a
α<0.017 unilateral lesion vs. bilateral normal;
b
α<0.017 unilateral lesion vs. bilateral lesion;
c
α<0.017 bilateral normal vs. bilateral lesion.
CT, computed tomography; BMI, body mass index; BP, blood pressure; DDD, defined daily dose; eGFR, estimated glomerular filtration rate; PAC, plasma aldosterone concentration; PRA, plasma renin activity; ARR, aldosterone-to-renin ratio; NA, not applicable.