Table 6.

Recommended Targeted Next-Generation Sequencing Panels of Pheochromocytoma and Paraganglioma Based on Current Evidence

Targeted panel	Gene
Basic (n=10)	FH, MAX, NF1, RET, SDHA, SDHB, SDHC, SDHD, TMEM127, VHL
Extended (n=15)	‘All basic panel genes’ plus EGLN1/PHD2, EPAS1, KIF1B, MET, SDHAF2

FH, fumarate hydratase; MAX, myc-associated protein X; NF1, neurofibromatosis 1; RET, rearranged during transfection; SDH, succinate dehydrogenase; TMEM127, transmembrane protein 127; VHL, von Hippel-Lindau; EGLN1/PHD2, egl-9 family hypoxia inducible factor 1/prolyl hydroxylase domain 2; EPAS1, endothelial PAS domain-containing protein 1; KIF1B, kinesin family member 1B; MET, receptor tyrosine kinase; SDHAF2, succinate dehydrogenase complex assembly factor 2.