TABLE 2.
Patient characteristics
| Study ID | Group | Age | Sex | Sfree | Type | Lat | Loc | Onset | Dur | Familial history | Birth complications | FC | Known neurological issues | Radiological MRI findings |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FBIP02 | Re | 32 | M | CFTB | R | T | 0 | 32 | N | N | Y | Meningitis when baby | None | |
| FBIP03 | Re | 33 | M | SFTB | L | F | 16 | 17 | N | N | N | None | ||
| FBIP04 | Re | 21 | F | F | R | F | 1.5 | 19.5 | N | Emergency c‐section | Y | None | ||
| FBIP05 | Re | 34 | M | F | U | F | 13 | 21 | N | N | N | Fluid effusion seen in the mastoid air cells, more on the right side | ||
| FBIP06 | Re | 18 | M | CF | L | F | 10 | 8 | N | N | N | Scattered T2 white matter focal hyperintensities, seen mainly in the subcortical white matter of the frontal lobes bilaterally | ||
| FBIP07 | Re | 51 | M | F | U | T | 14 | 37 | N | N | Y | Encephalitis when infant | Increased T2 signal with loss of volume of the body and tail of the hippocampi bilaterally. Likely bilateral mesial temporal sclerosis | |
| FBIP08 | nRe | 26 | M | 2 | SFTB | U | U | 24 | 2 | N | N | N | None | |
| FBIP09 | nRe | 48 | F | 3 | SFTB | R | T | 12 | 36 | N | N | N | Pineal cyst measuring about 1.2 cm in maximum dimension, a few scattered tiny foci of T2 hyperintensity seen in the subcortical and deep white matter of the frontal lobes bilaterally. Mega cisterna magna (incidental) | |
| FBIP10 | Re | 50 | F | CFTB | U | U | 18 | 32 | N | N | N | Slight upward convexity of the upper margin of the pituitary (incidental) | ||
| FBIP11 | Re | 32 | M | CFTB | R | T | 23 | 9 | N | N | N | Quadrigeminal plate lipoma, mega cisterna magna (incidental) | ||
| FBIP12 | Re | 51 | F | CF | R | T | 11 | 40 | Y | N | N | Slightly increased T2 hyperintensity in right hippocampus, subtle hippocampal volume asymmetry. Suspicion of right mesial temporal sclerosis | ||
| FBIP13 | nRe | 24 | F | 3 | R | T | 21 | 3 | N | N | N | Temporal horn of the right lateral ventricle slightly more prominent compared to the left; no evidence of mesial temporal sclerosis | ||
| FBIP14 | Re | 36 | F | CFTB | U | U | 20 | 16 | N | N | N | Borderline loss of cerebellar volume | ||
| FBIP15 | Re | 38 | F | CFTB | L | F | 17 | 21 | Y | N | N | Lesion seen at the posterior aspect of the left frontal lobe; mild generalized loss of cerebellar volume | ||
| FBIP16 | Re | 48 | F | CFTB | U | T | 10 | 38 | N | N | N | None | ||
| FBIP17 | Re | 41 | F | CFTB | U | U | 27 | 14 | N | Premature | N | Focal encephalomalacia/gliosis seen in the left lateral orbital gyrus, anterior aspect of the left temporal lobe; borderline loss of cerebellar volume | ||
| FBIP18 | nRe | 33 | M | 1 | CFTB | U | U | 29 | 4 | N | N | N | 10 mm × 6 mm dural‐based structure seen at the left posterior temporal/occipitotemporal region; appearances compatible with meningioma | |
| FBIP19 | Re | 28 | M | R | T | 13 | 15 | N | N | N | Right hippocampus sclerosis | |||
| FBIP20 | nRe | 46 | F | 1.5 | CFTB | U | U | 22 | 24 | N | N | N | Upward convexity of the upper margin of the pituitary (incidental) | |
| FBIP21 | nRe | 60 | M | 1 | SFTB | U | R | 56 | 4 | Y | N | N | None | |
| FBIP22 | nRe | 38 | F | 5 | SFTB | R | T | 30 | 8 | U | U | N/K | Poss encephalitis—not confirmed | None |
| FBIP24 | Re | 58 | F | SFTB | U | U | 11 | 47 | N | U | N | Right‐sided subependymal gray matter heterotopia along ventricular trigone and temporal and occipital horns of lateral ventricle Polymicrogyria extending from the periventricular heterotopic gray matter Additional closed lip schizencephaly and dysplasia Right‐sided cerebellar volume loss. Cerebellar atrophy | ||
| FBIP25 | nRe | 44 | M | 5 | SFTB | R | T | 39 | 5 | N | N | N | Car accident when 15, brain injury | Encephalomalacia/gliosis in the left gyrus rectus and medial orbital gyrus. Focal damage in right temporal pole. Small focus of gliosis/encephalomalacia is close to left temporal bone. Mild periventricular T2 hyperintensity adjacent to the left ventricular trigone/supratrigonal white matter |
| FBIP26 | nRe | 26 | M | 2 | CFTB | U | T | 21 | 5 | Y | N | N | Right hippocampus marginally smaller than the left | |
| FBIP27 | nRe | 29 | F | 3 | CF | U | U | 22 | 7 | N | N | N | None | |
| FBIP28 | nRe | 35 | M | 2 | CFTB | R | F | 31 | 4 | N | N | N | Accident when 11, brain injury | Encephalomalacia/gliotic changes in right frontal lobe extending to left frontal lobe. Some anterior corpus callosum volume loss. Gliotic/encephalomalacia changes in the left parietal lobe. Subtle volume loss of right temporal pole |
| FBIP29 | nRe | 59 | F | 4.5 | SFTB | U | U | 54 | 5 | N | 3 months premature | Y | Mild‐to‐moderate small vessel ischaemia | |
| FBIP30 | nRe | 54 | M | 11 | SFTB | L | T | 43 | 11 | N | Spina bifida, hydocephalus | Y | Hydrocephalus when born | Right‐sided frontal porencephalic cyst with surrounding gliotic changes Smaller porencephalic cyst in the left frontal lobe. Atrophy of the anterior aspect of the body of the corpus callosum Mild enlargement of the lateral and third ventricles secondary white matter volume loss. |
| FBIP31 | nRe | 51 | F | 3 | SFTB | L | F | 48 | 3 | U | U | N | Gliosis of anterior left superior frontal gyrus Mild generalized brain volume loss. Mild small vessel type ischaemic changes in white matter adjacent to anterior aspect of right lateral ventricle | |
| FBIP32 | nRe | 38 | F | 0.75 | CFTB | U | U | 36 | 2.5 | Y | N | N | Enlarged ventricles | Heterotopic subependymal gray matter nodules seen along the body of the right lateral ventricle |
Abbreviations: CF, complex focal seizures; CFTB, complex focal to bilateral seizures; Dur, duration of epilepsy; F, focal seizures (unknown whether simple or complex); FC, febrile seizures; FH, family history of epilepsy; Fr, frontal; L, left; Lat, lateralization (left / right); Loc, localization (lobar); N, no; nRe, nonrefractory; Re, refractory; R, right; SF, simple focal seizures; SFree, number of years seizure free; SFTB, simple focal to bilateral seizures; T, temporal; U, unresolved; Y, yes.