TABLE 4.
Fiber ball white matter modeling (FBWM) significant differences between patients with refractory epilepsy, nonrefractory epilepsy and controls
| Parameters | Tract | Controls | Refractory | αFWE | Min p‐value | t‐value | Cohen's d |
|---|---|---|---|---|---|---|---|
| AWF | L ST PREM | 0.56 (0.04) | 0.50 (0.07) | 0.001125 | .000537 | −3.91 | 1.39 |
| FAE | R ICP | 0.18 (0.10) | 0.26 (0.10) | 0.002152 | .001075 | 3.65 | −1.30 |
| MDe | R ICP | 0.97 (0.20) | 1.39 (0.45) | 0.002295 | 7.40E‐05 | 4.64 | −1.65 |
| L SCP | 1.17 (0.13) | 1.45 (0.23) | 0.000558 | .000292 | 4.14 | −1.47 | |
| De,II | R ICP | 1.30 (0.26) | 1.82 (0.61) | 0.002143 | .00017 | 4.34 | −1.54 |
| L SCP | 1.76 (0.26) | 2.22 (0.39) | 0.000665 | .000386 | 4.03 | −1.43 | |
| L ST PREM | 1.36 (0.10) | 1.56 (0.20) | 0.001006 | .000451 | 3.97 | −1.41 | |
| De,⊥ | R AF | 0.74 (0.05) | 0.83 (0.08) | 0.000969 | .000503 | 3.93 | −1.40 |
| L ATR | 0.77 (0.03) | 0.82 (0.05) | 0.001134 | .000104 | 4.52 | −1.61 | |
| L FPT | 0.71 (0.05) | 0.79 (0.07) | 0.000745 | 3.70E‐05 | 4.89 | −1.74 | |
| L ICP | 0.71 (0.08) | 0.87 (0.19) | 0.002178 | .001242 | 3.59 | −1.28 | |
| R ICP | 0.81 (0.18) | 1.17 (0.39) | 0.00254 | 5.00E‐05 | 4.79 | −1.70 | |
| L T PREM | 0.74 (0.02) | 0.79 (0.05) | 0.000724 | .000315 | 4.11 | −1.46 | |
| FAA | R ICP | 0.28 (0.14) | 0.48 (0.07) | 0.002887 | 2.00E‐06 | 6.03 | −2.14 |
| ζ | R CG | 0.32 (0.02) | 0.29 (0.02) | 0.000618 | .000516 | −3.92 | 1.39 |
| R ICP | 0.15 (0.08) | 0.21 (0.05) | 0.002866 | .000377 | 4.04 | −1.44 | |
| R ILF | 0.24 (0.03) | 0.19 (0.03) | 0.000944 | .000479 | −3.95 | 1.40 | |
| R SLF III | 0.39 (0.02) | 0.36 (0.02) | 0.000781 | .000219 | −4.24 | 1.51 | |
| R UF | 0.23 (0.03) | 0.18 (0.03) | 0.001022 | .000909 | −3.71 | 1.32 | |
| Controls | Nonrefractory | ||||||
| Da | L STR | 2.10 (0.27) | 2.50 (0.31) | 6.00E‐04 | .000565 | −3.89 | 1.38 |
| De,II | R T PAR | 1.18 (0.05) | 1.30 (0.10) | 0.000451 | .000163 | −4.35 | 1.55 |
| R T OCC | 1.21 (0.06) | 1.37 (0.13) | 0.000484 | .000171 | −4.33 | 1.54 | |
| De,⊥ | L ATR | 0.76 (0.03) | 0.85 (0.06) | 0.000758 | 3.00E‐06 | −5.81 | 2.06 |
| L T PREM | 0.69 (0.03) | 0.75 (0.04) | 0.000754 | .000199 | −4.28 | 1.52 | |
| FA | CC1 | 0.37 (0.04) | 0.31 (0.05) | 0.002028 | .000699 | 3.81 | −1.35 |
| FAA | R STR | 0.61 (0.02) | 0.65 (0.03) | 0.000539 | .000229 | −4.23 | 1.50 |
| MD | L ATR | 0.91 (0.05) | 0.98 (0.04) | 0.000683 | .000113 | −4.48 | 1.59 |
| Refractory | Nonrefractory | ||||||
| MDe | R CST | 1.11 (0.07) | 1.02 (0.05) | 0.001903 | .001867 | 3.44 | −1.22 |
| R ICP | 1.36 (0.13) | 1.17 (0.21) | 0.001822 | .000732 | 3.79 | −1.35 | |
| De,II | R ICP | 1.86 (0.20) | 1.63 (0.25) | 0.003316 | .001363 | 3.56 | −1.26 |
| De,⊥ | L FPT | 0.79 (0.05) | 0.71 (0.03) | 0.000809 | 5.60E‐05 | 4.74 | −1.69 |
| R ICP | 1.11 (0.17) | 0.94 (0.23) | 0.002599 | .000789 | 3.76 | −1.34 | |
| FA | R SCP | 0.44 (0.05) | 0.37 (0.05) | 0.003208 | .001382 | 3.55 | −1.26 |
| FAA | L OR | 0.63 (0.03) | 0.67 (0.03) | 0.000264 | .000237 | −4.21 | 1.50 |
| L T OCC | 0.62 (0.02) | 0.67 (0.03) | 0.000253 | .00011 | −4.50 | 1.60 | |
| MD | R CST | 1.14 (0.08) | 1.01 (0.08) | 0.00058 | 1.10E‐05 | 5.33 | −1.89 |
| L FPT | 1.04 (0.05) | 0.93 (0.05) | 0.000512 | 1.90E‐05 | 5.15 | −1.83 | |
| R ICP | 1.13 (0.09) | 1.04 (0.12) | 0.003937 | .002445 | 3.33 | −1.18 | |
| L POPT | 1.08 (0.08) | 0.96 (0.08) | 0.000644 | .00013 | 4.43 | −1.58 | |
| R POPT | 1.22 (0.11) | 1.05 (0.10) | 0.000544 | 8.40E‐05 | 4.59 | −1.63 | |
| ζ | MCP | 0.44 (0.05) | 0.36 (0.07) | 0.005229 | .001876 | 3.43 | −1.22 |
| R SCP | 0.32 (0.05) | 0.26 (0.06) | 0.003404 | .001244 | 3.59 | −1.28 |
Note: The mean (SD) of the individual diffusion parameter, minimum p‐value and its corresponding α value, t statistic, and Cohen's d for the peak of each significant tract are provided. Diffusivities are expressed in units of μm2/ms, while ζ values are in units of ms1/2/ μm; all other quantities are dimensionless. Abbreviations for parameters are provided in Table 1 and for tracts in Table 3.