. 2021 Mar 26;42(8):2434–2444. doi: 10.1002/hbm.25377

TABLE 3.

The association of insulin resistance and MetS with MRI global measures

	Difference (95% CI) in volume (mm³) or thickness (mm)
FSI (per SD)	−2,438 (−5,448, 572)	1,363 (−544, 3,270)	115 (−102, 332)	−2944 ^* (−4,468, −1,419)	−0.008 ^* (−0.014, −0.003)
HOMA‐IR (per SD)	−2,824 (−6,110, 461)	1,251 (−832, 3,333)	124 (−113, 361)	−3231 ^* (−4,895, −1,567)	−0.010 ^* (−0.016, −0.004)
MetS: with versus without	−9,606 (−18,202, −1,010)	344 (−5,115, 5,802)	59 (−563, 680)	−9275 ^* (−13,627, −4,922)	−0.032 ^* (−0.047, −0.016)

Difference (95% CI) in volume (mm³) or thickness (mm)

TBV

WMV

Subcortical GMV

Cortical GMV

Mean cortical thickness

FSI (per SD)

−2,438

(−5,448, 572)

1,363

(−544, 3,270)

115

(−102, 332)

−2944 ^*

(−4,468, −1,419)

−0.008 ^*

(−0.014, −0.003)

HOMA‐IR (per SD)

−2,824

(−6,110, 461)

1,251

(−832, 3,333)

124

(−113, 361)

−3231 ^*

(−4,895, −1,567)

−0.010 ^*

(−0.016, −0.004)

MetS: with versus without

−9,606

(−18,202, −1,010)

344

(−5,115, 5,802)

(−563, 680)

−9275 ^*

(−13,627, −4,922)

−0.032 ^*

(−0.047, −0.016)

Note: Values represent age‐ and sex‐adjusted beta (95% CI) values from linear regression models on associations between each metabolic measure and MRI global measures. Volumetric measures were additionally adjusted for head size assessed by the Estimated Total Intracranial Volume (eTIV).

Abbreviations: FSI, fasting serum insulin; GMV, gray matter volume; HOMA‐IR, homeostasis model assessment of insulin resistance; MetS, metabolic syndrome; TBV, total brain volume; WMV, white matter volume.

^{^*}

p < 0.0033, that is, the Bonferroni‐adjusted cut‐off value.