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. 2021 Feb 8;40(9):e107015. doi: 10.15252/embj.2020107015

Figure EV2. CTD shortening leads to minor changes in Pol II pausing at steady state.

Figure EV2

  • A, B
    Spearman correlation of read counts in the first constitutive exon of genes encoding major isoforms in biological replicates of PRO‐seq data.
  • C, D
    Scatter plot of pausing duration (d) and productive initiation frequencies (I) in genes encoding major isoforms in RPB1‐52R and RPB1‐25R cells. The gray‐shaded area depicts impossible combinations of I and d according to published kinetic theory (Ehrensberger et al, 2013).
  • E, F
    Histogram of distances from the PAS to the transcription termination site (TTS) of genes encoding major isoforms.