Table 1.

Seven compounds and their effects on invasion, autophagy modification and lysosomal membrane permeabilization

For MT2 spheroid invasion evaluation, the most efficient invasion inhibiting concentrations were used for each compound. For the evaluation of OVC316 tumor organoid invasion, 2,5 µM drug concentrations were used. The ability to induce LMP was evaluated as “early” if Gal3 puncta formation (3 or more puncta per cell) was evident before 12 h and “late” if it became evident after 12 h.