Table 3.
Pre–post intervention data for 33 program completers
| Variable | Baseline | 6-Month | Median (IQR) Δ Pre–Post | P-value |
|---|---|---|---|---|
| Waist circumference (in) | 42.5 (40.7–46) | 43.7 (41–47) | 0.5 (− 0.75, 1.9) | 0.04 |
| Weight (lb) | 200 (186–236) | 207 (185.1–229.4) | 0.5 (− 5, 7) | 0.56 |
| BMI | 33.6 (29.6–35.3) | 32.3 (29.7–35.9) | − 0.3 (− 0.78, 1.0) | 1.0 |
| SBP mmHg | 132(126–142) | 131 (120–136) | 3 (− 3, 10) | 0.16 |
| ALT (U/L) | 55 (40.5–70.5) | 44 (29–75.5) | − 2.5 (− 14, 5) | 0.31 |
| HDL (mg/dL) | 44 (39–55) | 49.5 (39–56) | 4 (− 1, 6) | < 0.01 |
| LDL (mg/dL) | 120 (80–134) | 100.5 (69–116.5) | − 7 (− 18, 1) | < 0.01 |
| TG (mg/dL) | 148 (122–227) | 137.5 (96.5–193.5) | − 22 (− 53, 11) | 0.03 |
| HgA1c | 5.9 (5.3–6.7) | 5.8 (5.4–6.6) | 0.1 (− 0.1, 0.2) | < 0.01 |
| Fibroscan kPA | 7 (4.8–10.3) | 7.6 (5.7–9.5) | 0 (− 2.3, 1.1) | 1.00 |
| Fibroscan F Score | − 1 (− 1, 1) | 0.67 | ||
| F0-2 | 19 (63%) | 21 (63.6%) | ||
| F3 | 3 (10%) | 7 (21.2%) | ||
| F4 | 8 (27%) | 5 (15.2%) | ||
| Fibroscan CAP (dB/m) | 327.5 (278–356) | 305 (254–354) | − 10.5 (− 54, 35) | 0.19 |
| 6MWT distance (feet) | 1585 (1295–1822) | 1725 (1495–1870) | 59.2 (− 19, 175) | < 0.01 |
| Post-test dyspnea (Borg scale: 0–10) | 2 (0–3) | 1 (0.5–2) | − 1 (− 2, 1) | 0.10 |
| Step count^ | 6088 (4848–7966) | 5336.90 (3757–8156) | − 203 (− 2038, 789) | 0.52 |
| HRQOL# T-score (SD) | ||||
| Physical function | 50.6(8.2) | 50.9 (8.2) | 0.3 | |
| Ability to participate in social roles | 55.9 (9.5) | 56.5 (8.7) | 0.6 | |
| Satisfaction with social roles | 51.5 (11.8) | 53.4 (10.1) | 1.9 | |
| Psychosocial illness impact | 48.1 (9.1) | 47.9 (8.5) | -0.2 | |
| Fatigue | 52.2(9.4) | 50.7 (8.9) | -1.5 | |
Bolded values indicate result was significant with P value of 0.05 or less
^General population median daily step count = 5117
#Negative change in symptoms (fatigue, satisfaction, psychosocial illness impact) indicate reduced symptom burden from baseline to end of intervention. Positive change in health and functioning indicate improved health/functioning from baseline to end of intervention. Results presented as T-scores (mean = 50; SD = 10); higher PROMIS T-scores reflect a greater level of the construct measured. To interpret changes in PROMIS scores, minimally important differences (MID) are used. MID for physical function 1.9–2; MID social roles and psychosocial impact 2.3–3.4; MID fatigue 3–5