Table 1.
Anti-PEG IgE and Anti-PEG IgG in Sera from Cases and Controls of PEG-associated Anaphylaxis.
| Clinic | Anti-PEG IgE | Anti-PEG IgG | |||||
|---|---|---|---|---|---|---|---|
| Lab ID | Positivity (Max MFI) | Titration | Inhibition | Positivity (Max MFI) | Titration | Inhibition | |
| PEG1 | Case | +++ (4,855) |
>512 | 100% | ++ (154,969) |
>16,384 | 100% |
| PEG2 | Case | + (1,076) |
>32 | 100% | ++ (109,079) |
>8,192 | 100% |
| PEG3 | Control | +/− (295) |
>4 | ND | + (39,826) |
>2,048 | 100% |
| PEG4 | Control | − (−86) |
ND | − (130) |
1 | ND | |
| PEG5 | Control | − (0) |
ND | − (4,603) |
>1 | ND | |
| PEG6 | Case | ++ (493) |
>90 | 100% | +++ (40,419) |
>10,000 | 100% |
| PEG7 | Case | ++ (291) |
>100 | 100% | +++ (78,647) |
>10,000 | 100% |
| PEG8 | Case | ++ (1,800) |
>90 | 100% | + (29,494) |
>2,500 | 100% |
| PEG9 | Case | + (4,058) |
>30 | 100% | ++ (160,690) |
>6,000 | 100% |
Note: Number of “+” was assigned based upon the titer., for IgE a titer >30 is +, >90 is ++, >512 is +++; for IgG a titer >2000 is +, >6000 is ++, >10000 is +++. Max MFI is the maximum difference of target and control beads. Titer is the dilution where target-control bead MFI becomes flat. “ND”, not done.