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. 2021 Apr 19;12:641848. doi: 10.3389/fphar.2021.641848

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Copyright © 2021 Song, Feng, Zhang, Deng, Yu, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Tanshinone IIA on pathology and apoptosis after MCAO in rat brains. Tanshinone IIA or control saline was injected into the tail vein at the indicated time after MCAO. After reperfusion, the rat brains were harvested. (A) Pathological changes of rat cortex tissues were detected by HE staining and Nissl staining, apoptotic cells in rat cortex were detected by TUNEL staining (Scale bar: 100 μm). (B) The apoptotic cells of different groups were calculated and shown. ###p < 0.001, compared with the Sham group, **p < 0.01, compared with the MCAO group. Sham, sham operation group; MCAO, middle cerebral artery occlusion; TanIIA, Tanshinone IIA, n = 3.