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. 2021 Apr 19;12:641848. doi: 10.3389/fphar.2021.641848

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Copyright © 2021 Song, Feng, Zhang, Deng, Yu, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tanshinone IIA regulated the polarization of microglia in rat cortex. Tanshinone IIA or control saline was injected into the tail vein at the indicated time after MCAO. After reperfusion, the rat brains were harvested. (A) Co-immunofluorescence staining of rat brain tissues for microglia marker Iba-1 (red) and M1 marker CD16/32 (green), (B) and the level of CD16/32⁺ Iba-1⁺ cells were analyzed and shown. (C) Co-immunofluorescence staining of rat brain tissues for microglia marker Iba-1 (red) and M2 marker CD206 (green), (D) the level of CD206⁺ Iba-1⁺ cells were analyzed and shown. ##p < 0.01, compared with the Sham group, *p < 0.05, compared with the MCAO group. Sham, sham operation group; MCAO, middle cerebral artery occlusion; TanIIA, Tanshinone IIA, BAY, BAY-11-7082, a NF-κB inhibitor, n = 3. (Scale bar: 200 μm).