FIG 3.

C. acnes catheter-associated infection elicits heightened leukocyte influx in the CSF compared to sterile postoperative inflammation. (A) Representative dot plots of CD11b and RP1 staining demonstrate CD45⁺ CD11b⁺ RP1⁺ neutrophils and CD45⁺ CD11b⁺ RP1^– monocytes/macrophages in the CSF of animals with C. acnes-infected versus sterile catheters at days 1 and 5 postinfection. (B and C) Percentages of CD45⁺ CD11b⁺ RP1^– monocytes/macrophages (B) and CD45⁺ CD11b⁺ RP1⁺ neutrophils (C). (D) Representative dot plots of CD4 and CD8 staining demonstrate CD45⁺CD3⁺CD4⁺ CD4 T cells and CD45⁺CD3⁺ CD8⁺ CD8 T cells in the CSF of animals with C. acnes-infected versus sterile catheters at days 1 and 5 postinfection. (E and F) Percentages of CD45⁺ CD3⁺ CD4⁺ CD4 T cells (E) and CD45⁺ CD3⁺ CD8⁺ CD8 T cells in the CSF (F).