TABLE 3.

GSEA most up- and downregulated gene sets

Gene set name	Gene set sizea	NES	−Log10(FDR)	Group
Interferon alpha beta signaling	42	−3.09	>4.05	Reactome pathway
Interferon signaling	117	−3.01	>4.05	Reactome pathway
Interferon gamma signaling	48	−3.00	>4.05	Reactome pathway
Cytokine signaling in immune system	221	−2.81	>4.05	Reactome pathway
Olfactory signaling pathway	230	−2.74	>4.05	Reactome pathway
Olfactory transduction	286	−2.68	>4.05	KEGG pathway
Defense response	218	−2.67	>4.05	GO biological process
Cytokine production	65	−2.54	>4.05	GO biological process
Cytokine-cytokine receptor interaction	215	−2.50	>4.05	KEGG pathway
Interleukin binding	24	−2.46	>4.05	GO molecular function
Class a1 rhodopsin like receptors	270	−2.44	>4.05	Reactome pathway
Inflammatory response	116	−2.41	>4.05	GO biological process
Immune response	203	−2.40	>4.05	GO biological process
JAK STAT signaling pathway	132	−2.37	>4.05	KEGG pathway
Defense response to bacterium	19	−2.37	>4.05	GO biological process
Cytokine activity	81	−2.32	3.95	GO molecular function
Detection of stimulus	45	−2.32	3.97	GO biological process
Response to bacterium	24	−2.32	4.00	GO biological process
Cytokine metabolic process	40	−2.32	4.02	GO biological process
IL-22bp pathway	16	−2.32	4.04	BioCarta pathway
Valine leucine and isoleucine degradation	42	2.44	>4.05	KEGG pathway
ACTAYRNNNCCCR unknown	425	2.31	>4.05	TF Motif
Activation of chaperone genes by xbp1s	43	2.31	>4.05	Reactome pathway
Propanoate metabolism	30	2.25	>4.05	KEGG pathway
Endoplasmic reticulum part	94	2.22	3.69	GO cellular component
Asparagine N-linked glycosylation	78	2.21	3.16	Reactome pathway
Mitochondrion	318	2.19	3.22	GO cellular component
Endoplasmic reticulum	275	2.18	3.19	GO cellular component
Isomerase activity	34	2.14	2.89	GO molecular function
Major histocompatibility complex class II antigen presentation	81	2.13	2.87	Reactome pathway
Endoplasmic reticulum membrane	83	2.12	2.79	GO cellular component
Fatty acid metabolism	38	2.10	2.70	KEGG pathway
N glycan biosynthesis	44	2.10	2.68	KEGG pathway
Nuclear envelope endoplasmic reticulum network	92	2.09	2.64	GO cellular component
Golgi apparatus part	97	2.06	2.42	GO cellular component
Mitochondrial part	128	2.04	2.34	GO cellular component
Nucleotide excision repair	46	2.04	2.35	Reactome pathway
Lysosome	114	2.04	2.31	KEGG pathway
Unfolded protein response	74	2.03	2.29	Reactome pathway
Endomembrane system	213	2.02	2.26	GO cellular component

^aNumber of genes in the gene set that overlap with the genes in the ranked list.