FIG 1.

Overall metabolic pathway integration and targets for intervention. Only metabolic pathways and inhibitors discussed in this review are shown. Adaptations unique to specific kinetoplastids and differences between mammalian and parasite metabolism are not displayed. Cofactors, additional reactants, conversion of oxaloacetate to pyruvate and pyruvate to oxaloacetate, energy cost, and urea and CO₂ production are also not drawn. Targeting of parasite versus host metabolic pathways are not differentiated, because this is often hard to distinguish when nonselective inhibitors are used. Metabolites are boxed.