. 2021 Apr 13;87(9):e02958-20. doi: 10.1128/AEM.02958-20

TABLE 1.

Linezolid resistance genes, antimicrobial susceptibility profiles, typing data, and gene locations

Strain	Species	Sampling site	Sample	Oxazolidinone resistance genes			MIC (mg/liter) of:^a						Typing results		Estimated plasmid size(s) (kb) from S1 PFGE and hybridization^b
Strain	Species	Sampling site	Sample	optrA	cfr	poxtA	FFC	CHL	LZD	TZD	TE	VAN	SmaI PFGE	MLST	optrA	poxtA
EN3	E. faecalis	EN	Sediment	+	−	−	128	128	4	4	128	1	ST585	20, 140
EF3	E. faecium	EF	Sediment	−	−	+	64	16	8	2	128	1	C	ST1710	30, c
ES2	E. faecium	ES	Sediment	−	−	+	32	16	8	2	128	1	C₁	ST1710	15, 30, c
TF3	E. faecium	TF	Sediment	−	−	+	64	32	2	2	>128	0.5	B	ST1711	30, 50, 80, c
GE5	E. hirae	GEN	Sediment	−	−	+	64	64	4	2	128	0.5	A₁	25, 100
GE2	E. hirae	GES	Zooplankton	−	−	+	64	64	8	3	128	0.5	A	25, 100

FFC, florfenicol; CHL, chloramphenicol; LZD, linezolid; TZD, tedizolid; TE, tetracycline; VAN, vancomycin. MIC resistance breakpoints (EUCAST or CLSI) were as follows: florfenicol, not applicable; chloramphenicol, resistant at ≥32mg/liter; linezolid, resistant at >4 mg/liter; tedizolid, susceptible at ≤0.5 mg/liter (only for E. faecalis); tetracycline, resistant at ≥16 mg/liter; vancomycin, resistant at >4 mg/liter.

c, chromosome.