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. 2021 Jan 30;30(3-4):182–197. doi: 10.1093/hmg/ddab022

Figure 1 .

Figure 1

Transgenic APOL1 risk variant expression in mice does not impair kidney function at baseline. (A) Urinary albumin-to-creatinine ratio in 7-week-old and 7-month-old APOL1 BAC transgenic mice (n = 9–10). (B) Representative TEM images to identify podocyte foot process in APOL1 BAC transgenic mice carrying G0 and G1 alleles (scale bars: 2 μm) and scatter plot quantification of podocyte foot process per μm of GBM (n = 3). (C) Total cholesterol and cholesterol ester contents in kidney cortices of APOL1 BAC transgenic mice, normalized to protein concentrations (n = 8–10). The error bars represent mean ± SD of biologically independent experiments. One-way ANOVA followed by Tukey’s test (A); Two-tailed Student’s t-test (B); One-way ANOVA followed by Dunnett’s test (C). *P < 0.05. #WT compared with G1, *G0 compared with G1.