Table A6.
Odds ratio and 95% confidence interval of the association between baseline rest-activity circadian rhythm and changed cognitive scores during the follow-up stratified by sex
| Male |
Female |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Rest-activity rhythms parameters 2 | Stable n = 71 |
Worsen n = 36 |
Better n = 35 |
Stable n = 71 |
Worsen n = 36 |
Better n = 35 |
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| N (%) | N (%) | Crude OR (95%CI) | Adjusted OR (95%CI) 2 | N (%) | Crude OR (95%CI) | Adjusted OR (95%CI) 2 | N (%) | N (%) | Crude OR (95%CI) | Adjusted OR (95%CI) 2 | N (%) | Crude OR (95%CI) | Adjusted OR (95%CI) 2 | |
| MESOR | ||||||||||||||
| ≤244.26 | 6 (40.0) | 1 (14.3) | 1.00 | 1.00 | 4 (57.1) | 1.00 | 1.00 | 20 (35.7) | 10 (34.5) | 1.00 | 1.00 | 7 (25.0) | 1.00 | 1.00 |
| 244.26- 315.69 | 4 (26.7) | 5 (71.5) | 7.50 (0.62–90.65) | 21.47 (0.74–62.00) | 2 (28.6) | 0.75 (0.09–6.23) | 2.98 (0.17–50.90) | 17 (30.4) | 9 (31.0) | 1.06 (0.35–3.21) | 1.29 (0.40–4.12) | 11 (39.3) | 1.85 (0.59–5.82) | 1.80 (0.55–5.86) |
| >315.69 | 5 (33.3) | 1 (14.3) | 1.20 (0.06–24.47) | 3.08 (0.08–12.22) | 1 (14.3) | 0.30 (0.03–3.63) | 1.02 (0.05–21.23) | 19 (33.9) | 10 (34.5) | 1.05 (0.40–2.95) | 1.46 (0.43–4.92) | 10 (35.7) | 1.50 (0.48–4.76) | 1.43 (0.41–5.00) |
| Amplitude | ||||||||||||||
| ≤109.60 | 5 (33.3) | 2 (28.6) | 1.00 | 1.00 | 5 (71.4) | 1.00 | 1.00 | 17 (30.4) | 9 (31.0) | 1.00 | 1.00 | 9 (32.1) | 1.00 | 1.00 |
| 109.60- 168.78 | 5 (33.3) | 3 (42.8) | 1.50 (0.17–13.23) | 0.36 (0.02–7.59) | 0 (0.0) | – | – | 17 (30.4) | 11 (37.9) | 1.22 (0.40–3.70) | 1.46 (0.45–4.70) | 12 (42.9) | 1.33 (0.45–3.99) | 1.20 (0.39–3.73) |
| >168.78 | 5 (33.3) | 2 (28.6) | 1.00 (0.01–10.17) | 0.87 (0.03–2.19) | 2 (28.6) | 0.40 (0.05–3.12) | 0.92 (0.05–1.82) | 22 (39.3) | 9 (31.0) | 0.77 (0.25–2.37) | 1.01 (0.29–3.52) | 7 (25.0) | 0.60 (0.19–1.94) | 0.50 (0.14–1.78) |
| Acrophase | ||||||||||||||
| ≤1:24pm | 2 (13.3) | 3 (42.9) | 1.50 (0.11–21.32) | 1.00 (0.05–2.19) | 3 (42.9) | 0.75 (0.06–8.83) | 0.56 (0.03–9.63) | 19 (33.9) | 12 (41.4) | 0.94 (0.32–2.78) | 0.95 (0.32–2.82) | 8 (28.6) | 0.57 (0.18–1.79) | 0.57 (0.18–1.79) |
| 1:24pm- 3:00pm | 2 (13.3) | 2 (28.6) | 1.00 | 1.00 | 4 (57.1) | 1.00 | 1.00 | 15 (26.8) | 10 (34.5) | 1.00 | 1.00 | 11 (39.3) | 1.00 | 1.00 |
| >3:00pm | 11 (73.3) | 2 (27.6) | 0.18 (0.02–2.15) | 0.11 (0.00–2.98) | 0 (0.0) | – | – | 22 (39.3) | 7 (24.1) | 0.48 (0.15–1.53) | 0.49 (0.15–1.59) | 9 (32.1) | 0.56 (0.19–1.67) | 0.55 (0.18–1.66) |
| Percent rhythm | ||||||||||||||
| ≤8.16 | 6 (40.0) | 4 (57.1) | 1.00 | 1.00 | 4 (57.1) | 1.00 | 1.00 | 18 (32.1) | 10 (34.5) | 1.00 | 1.00 | 7 (25.0) | 1.00 | 1.00 |
| 8.16–12.28 | 3 (20.0) | 1 (14.3) | 0.50 (0.04–6.69) | 0.52 (0.03–9.21) | 3 (42.9) | 1.50 (0.20–1.15) | 2.22 (0.21–2.34) | 17 (30.4) | 11 (37.9) | 1.16 (0.39–3.44) | 1.15 (0.39–3.41) | 9 (32.1) | 1.36 (0.41–4.48) | 1.37 (0.42–4.52) |
| >12.28 | 6 (40.0) | 2 (28.6) | 0.50 (0.07–3.85) | 0.04 (0.24–5.97) | 0 (0.0) | – | – | 21 (37.5) | 8 (27.6) | 0.69 (0.22–2.11) | 0.73 (0.23–2.26) | 12 (42.9) | 1.47 (0.48–4.53) | 1.45 (0.47–4.49) |
Abbreviations: OR, odds ratio; CI, confidence intervals, MESOR = Midline statistic of rhythm.
1 Adjusted for the age at interview and education attainment in years.
2 All rest-activity rhythms parameters were stratified based on their tertile distribution.