Table 4.

Odds ratio and 95% confidence interval of the association between changes of rest-activity circadian rhythm and changed cognitive scores between baseline and follow-up measurements.

Changes of rest-activity rhythms parameters b	Stable n = 71	Worsen n = 36			Better n = 35
	N (%)	N (%)	Crude OR (95%CI)	Adjusted OR (95%CI) a	N (%)	Crude OR (95%CI)	Adjusted OR (95%CI) a
MESOR
≤-31.62	19 (28.8)	12 (36.4)	1.61 (0.56–4.64)	1.62 (0.56–4.75)	13 (39.41)	1.43 (0.52–3.92)	1.48 (0.53–4.13)
-32.62-15.84	23 (34.8)	9 (27.3)	1.00	1.00	11 (33.3)	1.00	1.00
>15.84	24 (36.4)	12 (36.4)	1.28 (0.45–3.60)	1.29 (0.45–3.68)	9 (27.3)	0.78 (0.27–2.24)	0.78 (0.27–2.24)
Amplitude
≤-22.84	20 (30.3)	13 (39.4)	1.24 (0.45–3.41)	1.39 (0.49–3.99)	11 (33.3)	1.05 (0.37–2.96)	1.15 (0.39–3.35)
-22.84-5.23	21 (31.8)	11 (33.3)	1.00	1.00	11 (33.3)	1.00	1.00
>5.23	25 (37.9)	9 (27.3)	0.69 (0.24–1.97)	0.77 (0.26–2.31)	11 (33.3)	0.84 (0.30–2.32)	0.93 (0.32–2.67)
Acrophase
≤-36 min	17 (25.8)	10 (30.3)	0.50 (0.16–1.56)	0.47 (0.14–1.55)	16 (48.5)	0.49 (0.18–1.30)	0.45 (0.16–1.27)
-36-24 min	24 (36.4)	7 (21.2)	1.00	1.00	11 (33.3)	1.00	1.00
>24 min	25 (37.9)	16 (48.5)	1.09 (0.40–2.96)	1.12 (0.41–3.12)	6 (18.2)	0.26 (0.08–0.78)	0.26 (0.08–0.79)
Percent rhythm
≤-2.12	23 (34.8)	10 (30.3)	0.56 (0.20–1.55)	0.58 (0.21–1.61)	11 (33.3)	0.78 (0.28–2.21)	0.79 (0.29–2.26)
-2.12-0.74	18 (27.3)	14 (42.4)	1.00	1.00	11 (33.3)	1.00	1.00
>0.74	25 (37.9)	9 (27.3)	0.46 (0.16–1.30)	0.46 (0.16–1.29)	11 (33.3)	0.72 (0.26–2.02)	0.72 (0.25–2.02)

Abbreviations: OR, odds ratio; CI, confidence intervals, MESOR = Midline statistic of rhythm.

^aAdjusted for the age at interview, sex, education attainment in years.

^bAll changes of rest-activity rhythms parameters were stratified based on their tertile distribution.