FIG 1.

Topological model of Tet38 was generated with the Protter interactive feature visualization (https://wlab.ethz.ch/protter/start/). The 14 transmembrane segments (T-1 to T-14) are indicated with their respective residues and positions. The 7 external loops are indicated with their respective positions (L1 to L7). The motifs B and C and the conserved residues R₁₀₆ and G₁₅₁ (shaded gray) are indicated based on the alignment of Tet38, TetK/L, and TetA/B using the ClustaL Omega and ConSurf servers. The motifs are as reported in Paulsen et al. (7).