Table 3.
Cell viability data in KB-3-1, KBCP20, A2780, A2780CP70, A549, A549 CisR, H460, H460 CisR, and MRC-5 cells. Error represents one standard deviation.
| IC50 (μM) or RFa of Complex | ||||
|---|---|---|---|---|
| Cell Line | Cisplatin | 9 | 10 | 13 |
| KB-3-1 | 1.0 ± 0.3 | 4.3 ± 1.6 | 0.77 ± 0.17 | 0.92 ± 0.20 |
| KBCP20 | 36 ± 7 | 5.3 ± 2.1 | 7.2 ± 1.2 | 1.6 ± 0.4 |
| RFa (KB-3-1) | 36 | 1.2 | 9.4 | 1.7 |
| A2780 | 0.23 ± 0.07 | 3.5 ± 2.8 | 2.2 ± 1.8 | 2.2 ± 0.2 |
| A2780CP70 | 8.2 ± 1.8 | 4.7 ± 1.4 | 2.8 ± 2.5 | 3.0 ± 0.7 |
| RFa (A2780) | 36 | 1.3 | 1.3 | 1.4 |
| A549 | 3.0 ± 1.8 | 5.2 ± 4.0 | 9.7 ± 4.1 | 6.7 ± 4.9 |
| A549 CisR | 12.4 ± 8.5 | 3.9 ± 4.6 | 5.7 ± 1.8 | 5.4 ± 1.8 |
| RFa (A549) | 4.1 | 0.8 | 0.6 | 0.8 |
| H460 | 0.75 ± 0.43 | 14 ± 1 | 9.0 ± 5.0 | 4.5 ± 0.7 |
| H460 CisR | 3.4 ± 1.6 | 21 ± 12 | 8.0 ± 2.1 | 5.3 ± 2.9 |
| RFa (H460) | 4.5 | 1.5 | 0.9 | 1.2 |
| MRC-5 | 0.43 ± 0.14 | 10.7 ± 0.5 | 6.0 ± 1.9 | 4.1 ± 0.9 |
a
RF is the resistance factor, which is the IC50 in the cisplatin-resistant cell line divided by the IC50 in the non-resistant matched cell line.