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. 2021 Apr 7;30:102665. doi: 10.1016/j.nicl.2021.102665

Fig. 2.

Fig. 2

Tau and neurofilament-light in CSF and blood. Biomarkers for axonal injury/neurodegenerastion (Neurofilament-light; NF-L and Tau) in blood (A-B) and cerebrospinal fluid (CSF; C-D). CSF samples from healthy controls were obtained from a separate cohort (N=19, 14 males, 5 females; mean age 26, range 21-25 years old), as previously published. (A, C) Symptomatic athletes who had attained repeated sports-related concussion (rSRC) had similar plasma tau levels when compared to controls. In contrast, plasma tau levels were significantly lower in traumatic brain injury (TBI) patients when compared to both healthy controls and rSRC athletes. In the CSF, the median tau levels tended to be lower in both concussed athletes and TBI patients than those of healthy controls. (B,D) Symptomatic rSRC athletes had similar levels of serum and CSF NF-L when compared to controls. In contrast, TBI patients had increased CSF and serum NF-L when compared to controls (*p<0.05). (E,F) CSF biomarker levels in male (M) and female (F) participants, significant changes indicated by *.