Bone hierarchical structure. The V, IV, and III levels construct the mechanical support structure for bone tissues, and the II and I levels construct the microenvironment for the bone tissue cells. These structures and components provide a biomimetic template for BTE scaffolds. HAP: hydroxyapatite; GAGs: glycosaminoglycans; NCPs: non-collagenous proteins. This Fig. is adapted from Refs. [[26], [27], [28], [29]].