Fig. 1.
The O-linked protein glycosylation pathway in N. elongata spp. glycolytica. The products of genes pglJ, pglK, pglM and pglN are responsible for the synthesis of UDP-di-N-acetylglucuronic acid that is used as a donor by the PglG glycosyltransferase in the extension of the UND-PP-disaccharide. PglGNelgly has relaxed specificity and minimally requires a UDP-glucuronic acid and accordingly PglJ. Although pglG is present in all human-associated Neisseria species, pglJ is not found in N. gonorrhoeae, N. meningitidis and N. lactamica. This situation provided the incentive to address the status of pglG in the latter species. OM, outer membrane; IM, inner membrane.