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. 2021 Apr 28;10:123–140. doi: 10.2147/ITT.S296161

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© 2021 Xu et al.

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Priming Raji cells with AZA modulates CAR T cell function in co-cultures. Pre-treatment with AZA promoted Raji cell killing (A), increased CAR T and hCD62L^– CD45RO⁺ T_em numbers (B and C) and increased proportion of IFNγ+ CAR T cells co-cultured with Raji cells, with IFNγ expression in CD3⁺ T cells measured in triplicate (D). Flow cytometry measurements of PD-L1/PD-L2 expression in Raji cells (E) and PD-1 expression in CAR T cells at the end of co-culture (F).