Table 2.
Efficiency (refers to the full cohort), design effect (refers to Simple Random Sampling) and power for SRS and Case-Control (CC) designs with hypothetical hazard ratio of the biomarker of interest (HRBM) of 1.3 and 1.5, biomarker common (25%), censoring rate ρ = 0.1, type I error 0.05
| SRS | Case-control | CC stratified by surrogate | CC stratified by risk factor | |
|---|---|---|---|---|
| Efficiency | ||||
| HRBM = 1.3 | 30.40% | 38.91% | 43.06% | 34.47% |
| HRBM = 1.5 | 25.98% | 36.26% | 38.51% | 32.73% |
| Design effect | ||||
| HRBM = 1.3 | – | 1.23 | 1.37 | 1.20 |
| HRBM = 1.5 | – | 1.22 | 1.36 | 1.18 |
| Power | ||||
| HRBM= 1.3 | 30.91% | 54.80% | 60.15% | 54.34% |
| HRBM= 1.5 | 58.35% | 68.10% | 70.65% | 65.40% |