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. 2021 Apr 19;12:639256. doi: 10.3389/fphar.2021.639256

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Copyright © 2021 Yang, Li, Xie, Wang, Wen, Zhao, Tao, Li, Tian and Sheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Astragalin promoted apoptosis and cell cycle arrest in colon cancer HCT116 cells. (A) The apoptosis test group of HCT116 cells treated with astragalin. (B–D) Expression of apoptotic proteins (caspase 3, cleaved caspase 3, caspase 6, caspase 7, caspase 8, caspase 9, Bax, Bcl2, and P53) in HCT116 cells. (E,F) Cells were exposed to different concentrations of astragalin, and the cell cycle was analyzed by flow cytometry. (G–I) Protein expression levels of CDK2, CDK4, Cyclin D1, Cyclin E, P21, and P27 determined by western blotting. Data are expressed as mean ± SEM from three independent experiments (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001 vs. 0.0 μg/ml.