Figure 7.

The SVZ niche is hypoxic. Transcription factors HIF-1α and HIF-2α are expressed intracellularly in the cytoplasm and nuclei of various types of cells in the SVZ of glioblastoma patient samples (A, B) including the ECs (A). HIF-1α expression is also strongly expressed in blood vessel walls (A). DAPI is used for nuclear counterstaining. Scale bars: A = 100 µm; B = 200 µm. Abbreviations: DAPI, 4′,6-diamidino-2-phenylindole; EC, ependymal cell; LV, lateral ventricle; HIF, hypoxia-inducible factor; SVZ, subventricular zone.