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Overall scheme showing dietary precursors of 1-methylhistidine and its proposed relevance in the development of hypertension. 1. Carnosinase catalyzes conversion of dietary anserine into ß-alanine and 1-methylhistidine predominantly in systemic circulation. 2. Cumulative exposure to dietary 1-methylhistidine may increase risk for both obesity and nonalcoholic fatty liver disease, two independent risk factors for hypertension.
