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. 2021 May 3;22:25. doi: 10.1186/s12860-021-00364-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — SEM images on collagen arrangement and cellularity at day 15 and 90 in mice. a Collagen fiber alignment at day 15 is unidirectional and organized in bundles. b At day 90, collagen arrangement appears to be disorganized with loose and multidirectional collagen fibers. c Day 15 maintains poor cellularity and is characterized by the presence of white blood cells (white arrows). d Cellularity at day 90 shows an increase in erythrocytes (white triangles), whereas white blood cells (white arrows) appear to be reduced in comparison to day 15