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Effects of tipifarnib on mRNA expression of HIF‐1α's downstream genes. Effects of tipifarnib (300 nm) treatment for 24 h on mRNA levels of LDHA, ALDOC, CA9, PDK1, ANGPTL4, PDK1, and VEGFA downstream genes of HIF‐1α were evaluated by real‐time RT‐qPCR. Data are expressed as means ± SEM and are representative of three independent experiments and statistically analyzed by two‐tailed Student's t‐test. N.S.: not significant, *P < 0.05, **P < 0.01 versus control.
