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. Author manuscript; available in PMC: 2021 Nov 10.
Published in final edited form as: J Control Release. 2020 Sep 3;327:788–800. doi: 10.1016/j.jconrel.2020.09.003

Figure 2:

Figure 2:

Adenovirus structure. A) Adenovirus capsid structure. The various hexon protein chains are colored in blues, penton protein in green, and hexon-interlacing protein in red. Trimer fiber inserts into green penton protein center (not shown). B) Hexon monomeric unit. Hypervariable loop 1 is shown on green and hypervariable loop 2 is shown in red. Alignment of hypervariable regions determined from [50] C) Side view of fiber knob from Ad2 (structurally similar to Ad5 and four shaft repeat motifs. D) Top view of fiber Ad5 fiber knob showing trimeric symmetry. PDB IDs: 6B1T (A, B) [51], 1QIU (C) [52], and 6HCN (D) [53]. Rendered with UCSF ChimeraX [25]. Print in color.