Table 1.

Anti-oxidant approaches so far examined that correct early diabetes-induced MRI retinal abnormalities.

• α-lipoic acid corrects  • Impaired autoregulation (IOVS, 2006 Sep; 47(9):4077-82)  • Subnormal rod manganese uptake (IOVS, 2007 Oct; 48(10):4753-8)  • Impaired subretinal space expansion (IOVS, 2015 Jan 8; 56(1):606-15) • Cu/Zn SOD overexpression corrects  • Subnormal rod manganese uptake (IOVS, 2009; 50(5):2351-8) • Peroxisome-targeted catalase corrects  • Subnormal rod manganese uptake (IOVS, 2015; 56(5):3095-102) • Retinaldehydes correct  • Subnormal rod manganese uptake (Mol Vis. 2012; 18:372-6)  • Impaired subretinal space expansion (in press, 2015)