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. 2021 Apr 30;20:93. doi: 10.1186/s12933-021-01285-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Major adverse cardiovascular event (MACE) or heart failure (HF) hospitalization risk in patients with T2DM in different categories of baseline BMI and BW loss following SGLT2i treatment. Cumulative incidence risk of MACE/HF for T2DM patients in different categories of baseline BMI and BW loss following SGLT2i treatment. a Neither baseline BMI nor posttreatment BW loss predicted the risk of MACE/HF hospitalization after multivariate adjustment (P for trend > 0.05). b *Risk of outcome was adjusted for age, sex, different SGLT2i drugs and dosage, baseline comorbidities as shown in Tables 1, 2, HbA1c, eGFR, and use of antiplatelet therapy, statin, angiotensin system inhibitor, and all anti-hypoglycemic agents. HF: heart failure; MACE: major adverse cardiovascular event AF: atrial fibrillation; CI: confidence interval; eGFR: estimated glomerular filtration rate; HbA1c: glycated hemoglobin A1c; aHR: adjusted hazard ratio; SGLT2i: sodium–glucose cotransporter 2 inhibitor; T2DM: type 2 diabetes mellitus; BMI: body mass index; BW: body weight; SE: standard error; MRA: mineralocorticoid receptor antagonist; TZD: thiazolidinedione