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. 2021 May 3;21:493. doi: 10.1186/s12885-021-08164-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — The effect of combined TMZ and celecoxib, or 2,5-DMC, or rofecoxib on the expression of β-catenin (CTNNB1) and its target genes after 48 h of treatment of A-172, T98G and U-138 MG cell lines. The concentration of compounds used in this assay provided at least 70% of cell viability. Means ± SEM from two separate experiments with three replicates in each are presented. The values were calculated as mRNA level in comparison with control cells treated with DMSO (expression equals 1). The asterisk (*) above the bar denotes statistically significant difference from the control group, p < 0.05