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. 2021 May 3;13:102. doi: 10.1186/s13148-021-01085-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — DNA methylation-based classification and tumor purity evaluation. a Left: distribution of the adult diffuse lower-grade glioma (dLGG) cases (n = 166) by methylation class prediction score. The vertical dotted line shows the threshold value of ≥ 0.84 for assignment to an established methylation class. Right: median methylation class score values by methylation classes. Black dots represent individual tumor cases in each methylation class. b Left: distribution of dLGG cases (n = 166) by tumor purity score estimated with InfiniumPurify [27, 28]. Right: median tumor purity score values by methylation classes (n = 166). IDH glioma: glioma IDH-mutant. GBM: glioblastoma IDH-wildtype. CT: control tissue. UNC: unclassified (non-classifiable cases with a class prediction score threshold ≥ 0.30). Other methylation classes: low-grade glioma, MYB/MYBL1, (anaplastic) pleomorphic xanthoastrocytoma, low-grade glioma, ganglioglioma and plexus tumor, pediatric B