Table 3.
Diagnostics by DNA methylation profiling of diffuse lower-grade gliomas with assigned methylation classes and subclasses (n = 126)
| Methylation class | Molecular biomarkers according to methylation profiling | ||||
|---|---|---|---|---|---|
| IDHa wt (n = 20) |
IDH mut (n = 106) |
Codel.b (n = 51) |
MGMTc unmeth (n = 24) |
MGMT meth (n = 102) |
|
| IDH glioma (n = 106) | |||||
| 1p/19q codeleted oligodendroglioma | 0 | 51 | 51 | 0 | 51 |
| Astrocytoma | 0 | 48 | 0 | 7 | 41 |
| High-grade astrocytoma | 0 | 7 | 0 | 2 | 5 |
| Glioblastoma IDH wt (n = 15) | |||||
| Mesenchymal | 3 | 0 | 0 | 3 | 0 |
| Midline | 1 | 0 | 0 | 0 | 1 |
| MYCN | 1 | 0 | 0 | 1 | 0 |
| RTK I | 3 | 0 | 0 | 2 | 1 |
| RTK II | 7 | 0 | 0 | 5 | 2 |
| Pleomorphic xanthoastrocytoma | 1 | 0 | 0 | 0 | 1 |
| Low-grade glioma MYB/MYBL1 | 1 | 0 | 0 | 1 | 0 |
| Control tissue | 3 | 0 | 0 | 3 | 0 |
aIDH, isocitrate dehydrogenase gene family, wildtype (wt) and mutated (mut)
bCodel., complete codeletion of 1p/19q chromosomal arms
cMGMT, O6-methylguanine-DNA methyltransferase promotor, methylated (meth) or unmethylated (unmeth)