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. 2021 Apr 20;59(5):e02047-20. doi: 10.1128/JCM.02047-20

TABLE 2.

Sensitivity and specificitya of IgM tests to diagnose acute MeV infections in the overall cohort, in the primary infection setting, and in the high Anti-MeV-IgG avidity setting

Group Measurement Result (range) for (%):
Test A Test B Test C Test D PCR (serum)b
Overall cohort (n = 370) Sensitivity 69.6 (63.2–75.3) 86.6 (81.5–90.5) 84.8 (79.4–89.0) 78.3 (72.4–83.3) 93.1 (88.9–95.8)
Specificity 89.5 (83.7–93.5) 92.2 (86.8–95.5) 90.9 (85.2–94.5) 81.1 (74.1–86.5)
Primary infection setting (n = 236) Sensitivity 72.3 (65.6–78.2) 87.2 (81.7–91.3) 86.2 (80.5–90.4) 83.0 (77.0–87.7) 94.7 (90.4–97.1)
Specificity 89.6 (77.8–95.5) 93.8 (83.2–97.9) 91.7 (80.5–96.7) 91.7 (80.5–96.7)
High anti-MeV-IgG avidity setting (n = 134) Sensitivity 51.7 (34.4–68.6) 82.8 (65.5–92.4) 75.9 (57.9–87.8) 48.3 (31.4–65.6) 82.8 (65.5–92.4)
Specificity 89.5 (82.2–94.1) 91.4 (84.5–95.4) 90.5 (83.4–94.7) 76.2 (67.2–83.3)
a

Diagnostic indices were calculated grading “borderline” results as “negative” using the cutoffs according to the manufacturer.

b

Diagnostic indices were calculated using PCR from any material as positive reference.

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