FIG 1.

Receiver operator characteristic (ROC) curve analyses of anti-HTLV-1 Ab data in serum (A) and CSF (B) to determine PA-positive and PA-negative samples. All samples from HAM/TSP patients, HCs, and NCs were categorized into PA positive and PA negative. In panel B, the upper left corner of the plot is displayed with enlargement. White, gray, and black circles in panel A represent performances of PA, CLIA, and CLEIA in serum, respectively. White, gray, and black diamonds in panel B represent those of PA, CLIA, and CLEIA in CSF, respectively. The asterisk and dagger in panel B represent the cutoff point where the Youden index (sensitivity + specificity – 1) is maximal in CLIA and CLEIA, respectively. White, gray, and black arrows represent the default cutoff points of PA, CLIA, and CLEIA, respectively.