TABLE 2.
Performance of anti-HTLV-1 Ab assays in CSF by CLIA and CLEIA compared with PA
| Assay | Result | Anti-HTLV-1 Ab in CSFa |
Totalc | |
|---|---|---|---|---|
| PA positive (HAM/TSP and HC-CSF+) | PA negative (HC-CSF− and NCb) | |||
| CLIA | Positive | 56 | 3 | 59 |
| Negative | 2 | 19 | 21 | |
| Totald | 58 (sensitivity, 96.6% [56/58]) | 22 (specificity, 86.4% [19/22]) | 80 | |
| CLEIA | Positive | 40 | 0 | 40 |
| Negative | 18 | 22 | 40 | |
| Totald | 58 (sensitivity, 69.0% [40/58]) | 22 (specificity, 100.0% [22/22]) | 80 | |
a
In anti-HTLV-1 antibody (Ab) assay in CSF, PA-positive or PA-negative results were regarded as true-positive or true-negative results, respectively. HC-CSF+, HC with PA-positive CSF; HC-CSF−, HC with PA-negative CSF.
b
All CSF samples from NCs (n = 18) were negative in all assays.
c
The total number represents the sum of the numbers of PA-positive and PA-negative samples in the same row.
d
The total number represents the sum of the numbers of PA-positive and PA-negative samples in the same column.