TABLE 3.
Inconsistency of CSF anti-HTLV-1 Ab results among assays
| Diagnosis | Sample no. | PA |
CLIA |
CLEIA |
|||
|---|---|---|---|---|---|---|---|
| Titer | Resulta | S/CO | Result | COI | Result | ||
| HAM/TSP | 1 | 32× | + | 8.25 | + | 0.3 | – |
| 2 | 32× | + | 6.93 | + | 0.2 | – | |
| 3 | 32× | + | 2.00 | + | 0.2 | – | |
| 4 | 16× | + | 7.09 | + | 0.3 | – | |
| 5 | 8× | + | 9.02 | + | 0.4 | – | |
| 6 | 8× | + | 5.57 | + | 0.2 | – | |
| 7 | 8× | + | 4.18 | + | 0.8 | – | |
| 8 | 8× | + | 2.49 | + | 0.1 | – | |
| HC | 1 | 64× | + | 33.07 | + | 0.7 | – |
| 2 | 8× | + | 10.44 | + | 0.2 | – | |
| 3 | 8× | + | 4.97 | + | 0.1 | – | |
| 4 | 8× | + | 4.73 | + | 0.4 | – | |
| 5 | 8× | + | 4.67 | + | 0.7 | – | |
| 6 | 8× | + | 1.52 | + | 0.1 | – | |
| 7 | 8× | + | 0.77 | – | 0.1 | – | |
| 8 | 4× | + | 2.03 | + | 0.2 | – | |
| 9 | 4× | + | 1.16 | + | 0.1 | – | |
| 10 | 4× | + | 0.13 | – | 0.1 | – | |
| 11 | <4× | – | 5.33 | + | 0.2 | – | |
| 12 | <4× | – | 1.49 | + | 0.1 | – | |
| 13 | <4× | – | 1.24 | + | 0.1 | – | |
a
Shown are CSF assay results inconsistent among assays. A plus or minus represents a positive or negative result in each assay. The results of CSF samples were inconsistent in 8 of 47 samples from HAM/TSP patients and 13 of 15 samples from HCs. The remaining 39 HAM/TSP patients with consistent results showed all positive. In the remaining 2 HCs with consistent results, one showed all positive (titer of 64×, S/CO of 52.76, and COI of 1.4), and the other showed all negative (titer of <4×, S/CO of 0.38, and COI of <0.1).