FIGURE 7.

PLP promotes microtubule organization to induce PGC formation. Cartoon model of PLP function during PGC development. The schematic shows normal (WT) PB protrusion during NC 10 requires PLP to promote microtubule organization at the centrosomes, which ensures efficient segregation of the germ plasm into the PGCs. However, loss of plp is associated with impaired microtubule organization, resulting in uneven and aberrant germ plasm distributions and a failure to completely partition the germ plasm into the nascent germ cells. Consequently, disruption of PLP abates PGC formation during Drosophila embryogenesis. NC, nuclear cycle; PGC, primordial germ cells; PLP, Pericentrin-like protein; WT, wild-type