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. Author manuscript; available in PMC: 2021 Jul 23.
Published in final edited form as: J Med Chem. 2020 Jul 7;63(14):7695–7720. doi: 10.1021/acs.jmedchem.0c00520

Table 5.

Cytotoxicity of Representative Compounds

CC50 (μM)
 therapeutic index
no. HepG2 A549 HepG2 A549
13 63.8 ± 9.3   76.7 ± 11.4   7   9
43 170.1 ± 15.4 252.2 ± 13.3 38 57
45 110.3 ± 12.4 116.3 ± 10.8 27 28
46 92.6 ± 12.6   67.7 ± 11.3 24 18
54 74.4 ± 12.5   75.7 ± 12.5 36 37
55 97.7 ± 13.1   93.3 ± 13.0 12 11