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Structural landmarks of MDM2 and MDMX proteins. Schematic representation of the key domains found in MDM2 and MDMX proteins from N terminus (left) to C terminus (right). Shown are their conserved p53 binding domains, acidic domains, and zinc finger regions, as well as their RING domains, which contain an NoLS; MDM2 alone has NLS and NES signal sequences. (NLS) Nuclear localization signal, (NES) nuclear export signal, (NoLS) nucleolar localization signal.
