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. 2021 May;31(5):747–761. doi: 10.1101/gr.269233.120

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© 2021 Giacopelli et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genome Research, is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — A hypomethylation signature involving STAT is associated with FLT3-ITD mutations. (A) Bubble scatterplot of transcription factor motif enrichment in hypomethylated regions in FLT3-ITD-mutated AMLs. Bubble size corresponds to the P-value, and color corresponds to transcription factor family. (B) Heatmap of the STAT hypomethylation signature with samples arranged by hierarchical clustering. (C) Distribution of STAT hypomethylation signature-positive (SHS+) samples across AML epitypes. (D) Breakdown of FLT3 mutations in SHS+ (left) and SHS− (right) groups.