. 2020 Oct 19;19(3):197–204. doi: 10.2450/2020.0025-20

Table I.

TACO criteria according to the International Society of Blood Transfusion (ISBT 2010)

Patients classified with a TACO should exhibit:
Acute onset or worsening respiratory distress during or up to 6 hours after transfusion; and Two or more of the following: evidence of acute or worsening pulmonary oedema based on clinical physical examination, and/or radiographic chest imaging; evidence for unanticipated cardiovascular system changes including development of tachycardia, hypertension, jugular venous distension and peripheral edema; evidence of fluid overload including any of the following: a positive fluid balance; response to diuretic therapy combined with clinical improvement; and change in the patient’s weight in the peri-transfusion period; elevation in natriuretic peptide (NP) levels (e.g., BNP or NT-pro BNP) to greater than 1.5 times the pretransfusion value. A normal post-transfusion NP is not consistent with a diagnosis of TACO; serial testing of NP levels in the peri-transfusion period may be helpful in identifying TACO.

Patients classified with a TACO should exhibit:

Acute onset or worsening respiratory distress during or up to 6 hours after transfusion; and
Two or more of the following:
1. evidence of acute or worsening pulmonary oedema based on clinical physical examination, and/or radiographic chest imaging;
2. evidence for unanticipated cardiovascular system changes including development of tachycardia, hypertension, jugular venous distension and peripheral edema;
3. evidence of fluid overload including any of the following: a positive fluid balance; response to diuretic therapy combined with clinical improvement; and change in the patient’s weight in the peri-transfusion period;
4. elevation in natriuretic peptide (NP) levels (e.g., BNP or NT-pro BNP) to greater than 1.5 times the pretransfusion value. A normal post-transfusion NP is not consistent with a diagnosis of TACO; serial testing of NP levels in the peri-transfusion period may be helpful in identifying TACO.

Definition: all patients should fulfill criteria “1)” and two or more of listed criteria in group “2)”. TACO: transfusion-associated circulatory overload.