Fig. 6.

Response of three pancreatic tumors to combination therapy. Mice bearing one of three PDAC tumors were treated with a gemcitabine or the following combination therapies: fractionated X-radiation and TH-302, fractionated radiation and gemcitabine, or gemcitabine and TH-302. Survival” was defined as tumor volume increasing by <2.5-fold from the original size. See Table 1 for statistical results on treatment benefit. Each combination treatment group was compared with untreated control group in Fig.5 by log-rank test. ***, p<0.001.